ChemicalBook > CAS DataBase List > 4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline

4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline

Product Name
4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline
CAS No.
190728-25-7
Chemical Name
4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline
Synonyms
Benzenam;4-(6,7-Dimethoxy-quinoL;Cabozantinib Amine Analog;Intermediate 1 of Cabozantinib;Cabozantinib Genotoxic Impurity I;4-[(6,7-dimethoxy-4-quinolinyl)oxy]-;4-(6,7-dimethoxy quinolinoxy) aniline;4-[(6,7-Dimethoxy-4-quinolyl)oxy]aniline;6,7-Dimethoxy-4-(4-aminophenoxy)quinoline;4-(4-Aminophenoxy)-6,7-dimethoxyquinoline
CBNumber
CB52652846
Molecular Formula
C17H16N2O3
Formula Weight
296.32
MOL File
190728-25-7.mol
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4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline Property

Melting point:
211.0 to 215.0 °C
Boiling point:
481.8±45.0 °C(Predicted)
Density 
1.246±0.06 g/cm3 (20 ºC 760 Torr)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
DMSO (Slightly, Sonicated), Methanol (Slightly)
form 
powder to crystal
pka
6.79±0.30(Predicted)
color 
Light yellow to Brown
InChI
InChI=1S/C17H16N2O3/c1-20-16-9-13-14(10-17(16)21-2)19-8-7-15(13)22-12-5-3-11(18)4-6-12/h3-10H,18H2,1-2H3
InChIKey
VXEQRXJATQUJSN-UHFFFAOYSA-N
SMILES
C1(N)=CC=C(OC2C3C(N=CC=2)=CC(OC)=C(OC)C=3)C=C1
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Safety

HS Code 
2933.49.7000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical
Product number
D5070
Product name
4-[(6,7-Dimethoxyquinolin-4-yl)oxy]aniline
Packaging
200mg
Price
$155
Updated
2024/03/01
TCI Chemical
Product number
D5070
Product name
4-[(6,7-Dimethoxyquinolin-4-yl)oxy]aniline
Packaging
1g
Price
$460
Updated
2024/03/01
Chem-Impex
Product number
43936
Product name
4-[(6,7-Dimethoxyquinolin-4-yl)oxy]aniline,≥98%(HPLC)
Purity
≥98%(HPLC)
Packaging
1G
Price
$540.8
Updated
2021/12/16
AK Scientific
Product number
J90694
Product name
4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenylamine
Packaging
1g
Price
$20
Updated
2021/12/16
Ambeed
Product number
A138452
Product name
4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline
Purity
97%
Packaging
5g
Price
$54
Updated
2021/12/16
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4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline Chemical Properties,Usage,Production

Uses

4-(6,7-Dimethoxy-Quinolin-4-Yloxy)-Phenylamine is used in preparation of Cabozantinib Defluorination impurity.

Chemical Reactivity

4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline is a primary alcohol that has been shown to catalyze the reaction of potassium carbonate with an alkali metal hydroxide to produce potassium. It has also been shown to be a base catalyst for the reaction of cyclopropanecarboxylic acid with an alcohol ester to produce high yield.

4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline Preparation Products And Raw materials

Raw materials

Preparation Products

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4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline Suppliers

Americas 1 China 173 Europe 1 India 9 Japan 1 United States 10 Global 195
Aladdin Scientific
Tel
+1-833-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57511
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354
Email
support@targetmol.com
Country
United States
ProdList
19973
Advantage
58
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View Lastest Price from 4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline manufacturers

Nanjing Fred Technology Co., Ltd
Product
4-[(6,7-Dimethoxyquinolin-4-yl)oxy]aniline 190728-25-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1 ton
Release date
2023-12-26
Henan Fengda Chemical Co., Ltd
Product
4-[(6,7-Dimethoxyquinolin-4-yl)oxy]aniline 190728-25-7
Price
US $200.00-1.00/KG
Min. Order
1KG
Purity
99%, 99.5% Sublimated
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-30
LY Global chemicals co.,ltd .
Product
BenzenaMine, 4-[(6,7-diMethoxy-4-quinolinyl)oxy]- 190728-25-7
Price
US $0.00/kg
Min. Order
1kg
Purity
98.0%min
Supply Ability
100kg
Release date
2023-03-11

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